Bioinks for 3D Bioprinting Research & Testing

3Dynamic Systems Ltd (3DS) and Bioink Solutions offer a newly formulated gelatin-based bio-ink (Gel4Cell®) is available for 3-D bioprinting of tissue structures. Unique features of this bioink include:


  • • Cellular compatible material

  • • High degree of printability and uniformity

  • • UV-cross linkable for structural stability

3D Bioprintability

Gel4Cell® provides proper bioprintability as follows.


  • • Appropriate Viscosity

  • • Rheological properties with a shear-thinning formulation

  • • High Bioprinting resolution

  • • High degree of Uniformity


A variety of concentrations of each component has been tested to achieve proper printing resolution and bioprinting uniformity.

Cell Viability

To determine the cell viability during the printing process, survival of 3T3 fibroblasts in the 3-D bioprinted structures was examined. Live/dead cell assays showed ≥ 90% cell survival on day 0, which was maintained through days 4 and 7. Data indicate that the Gel4Cell® maintained the cell viability during the printing process and provided a proper microenvironment for cell proliferation.




3D BioPrinting Condition

  • • 3D Bioprinted on a 3Dynamic Omega

  • • Cell source: 3T3 cells (1x106 cells/ml)

  • • Print speed: 10 mm/min

  • • Nozzle size: 300 µm Teflon nozzle

3D Structural Stability

The 3D-Bioprinted constructs made by Gel4Cell® maintained their structure throughout the complete time. To evaluate structural stability of the Gel4Cell® in culture condition, dimension of the printed constructs were analysed. Approx. 70% of dimension change was observed at 21 days after bioprinting.

Advanced Bioinks

The Gel4Cell® kit can be conjugated with growth factor-mimetic peptides for bioprinting of 3D structures. The Gel4Cell® -BMP has been developed for bone tissue engineering applications, the Gel4Cell® -VEGF has been developed for accelerating vascularisation when implanted, and the Gel4Cell®-TGF has been developed for cartilage tissue engineering applications.


3DSBioInk-BMP

  • • Base bioink material: Gel4Cell

  • • BMP-2 mimetic peptide conjugated into Gel4Cell

  • • Cell compatible & osteoinductive material

  • • High printability and uniformity

  • • UV-crosslinkable for structural stability


3DSBioInk-VEGF

  • • Base bioink material: Gel4Cell

  • • VEGF mimicking peptide conjugated into Gel4Cell

  • • Cell compatible & angiogenic material

  • • High printability and uniformity

  • • UV-crosslinkable for structural stability


3DSBioInk-TGF

  • • Base bioink material: Gel4Cell

  • • TGF-mimetic peptide conjugated into Gel4Cell

  • • Cell compatible & chondrogenic material

  • • High printability and uniformity

  • • UV-crosslinkable for structural stability

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